Effect of endurance training on lipid metabolism in women: a potential role for PPARalpha in the metabolic response to training.

نویسندگان

  • J F Horowitz
  • T C Leone
  • W Feng
  • D P Kelly
  • S Klein
چکیده

Endurance training increases fatty acid oxidation (FAO) and skeletal muscle oxidative capacity. However, the source of the additional fat and the mechanisms for increasing FAO capacity in muscle are not clear. We measured whole body and regional lipolytic activity and whole body and plasma FAO in six lean women during 90 min of bicycling exercise (50% pretraining peak O(2) consumption) before and after 12 wk of endurance training. We also assessed skeletal muscle content of peroxisome proliferator-activated receptor-alpha (PPARalpha) and its target proteins that regulate FAO [medium-chain and very long chain acyl-CoA dehydrogenase (MCAD and VLCAD)]. Despite a 25% increase in whole body FAO during exercise after training (P < 0.05), training did not alter regional adipose tissue lipolysis (abdominal: 0.56 +/- 0.26 and 0.57 +/- 0.10 micromol x 100 g(-1) x min(-1); femoral: 0.13 +/- 0.07 and 0.09 +/- 0.02 micromol x 100 g(-1) x min(-1)), whole body palmitate rate of appearance in plasma (168 +/- 18 and 150 +/- 25 micromol/min), and plasma FAO (554 +/- 61 and 601 +/- 45 micromol/min). However, training doubled the levels of muscle PPARalpha, MCAD, and VLCAD. We conclude that training increases the use of nonplasma fatty acids and may enhance skeletal muscle oxidative capacity by PPARalpha regulation of gene expression.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Effect of Eight Weeks\' Endurance Training along with Fenugreek Ingestion on Lipid Profile, Body Composition, Insulin Resistance and VO2max in Obese Women\'s with Type2 Diabetes

Background: Physical activity combined with some herbal supplementations can affect body energy metabolism, blood lipids and physical fitness levels. However, the effect of exercise training combined with fenugreek on lipid metabolism and body composition in patients with type2 diabetes is unknown. Objective: The aim of present study was to investigate the effects of eight weeks&rsquo; enduran...

متن کامل

The Effects of Pyruvate Dehydrogenase Kinase 4 (PDK4) Inhibition on Metabolic Flexibility during Endurance Training in Skeletal Muscles of Streptozotocin-induced Diabetic Rats

Background:Metabolic flexibility is the capacity of a system to adjust fuel (primarily glucose and fatty acids) oxidation based on nutrient availability. Pyruvate Dehydrogenase Kinase 4 (PDK4) is one of the main enzymes that play a critical role in metabolic flexibility. In current study, we examined PDK4 inhibition along with exercise training (ET) on the gene expression of Es...

متن کامل

THE EFFECT OF ENDURANCE TRAINING IN MATERNAL METABOLIC SYNDROME WITH METFORMIN ON OXIDANT AND ANTIOXIDANT CAPACITY IN THEIR NEONATES

Background: High oxidative stress in pregnant women leads to pathogenesis or progression of disease in newborns. The aim of this study was to investigate the Effect of Endurance Training in Maternal Metabolic Syndrome with Metformin on Oxidant and antioxidant Capacity in their Neonates. Methods: To implementation of this experimental research, 16 female Wistar rats weighing 100 ± 20 gr randoml...

متن کامل

Effect of Endurance Training and MitoQ on Expression of PGC-1α, ERR-α, MCAD, and CPT-1α Genes in Skeletal Muscle of Male Wistar Rats

 Background and purpose: Estrogen-related receptor α (ERR-α) and transcriptional activator (PGC-1α) are important factors involved in regulating cellular energy. The aim of this study was to evaluate the expression of PGC1α, ERRα genes after six weeks of endurance training and MitoQ supplementation in skeletal muscle of male Wistar rats and to determine their role in lipid metabolism indices. ...

متن کامل

The Effect of Combined Training (Endurance- Resistance) and Ginger Supplementation on Cardiorespiratory Endurance, Body Composition and Insulin Resistance among Obese Females with Type 2 Diabetes

Background & objectives: Diabetes mellitus, as a metabolic disease, is associated with impaired insulin resistance index and cardiovascular risk factors. The purpose of this study was to investigate the effect of a concurrent exercise and Ginger supplementation on cardiorespiratory endurance, body composition, and insulin resistance index in obese women with type 2 diabetes. Methods: 60 women ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • American journal of physiology. Endocrinology and metabolism

دوره 279 2  شماره 

صفحات  -

تاریخ انتشار 2000